منابع مشابه
Exceptional Responders Inspire Change: Lessons for Drug Development From the Bedside to the Bench and Back.
Targeted therapies have changed the landscape of cancer treatment.Unfortunately, thepromiseof “targeted therapy” still fails too many patients with advanced cancer. Oncologists should ask why and how can we rapidly develop novel strategies. In medicine, exciting and novel occurrences are often first publicized as a case report. This quick yet detailed description of the clinical presentation, d...
متن کاملNanomedicine for tuberculosis: Insights from animal models
Patient noncompliance to current tuberculosis (TB) therapy owing to multidrug administration daily leads to treatment failure and emergence of multidrug resistant and extensively drug resistant TB. To avoid the daily dosing, application of nanotechnology is the only viable solution by virtue of sustained release of drugs. Other potential advantages of the system include the possibility of selec...
متن کاملHow to Model Heterogeneity in Costly Punishment: Insights from Responders' Response Times
We investigate what processes may underlie heterogeneity in social preferences. We address this question by examining participants’ decisions and associated response times across 12 mini-ultimatum games. Using a finite mixture model and cross-validating its classification with a response time analysis, we identified four groups of responders: one group takes little to no account of the proposed...
متن کاملMode of action and pharmacogenomic biomarkers for exceptional responders to didemnin B
Modern cancer treatment employs many effective chemotherapeutic agents originally discovered from natural sources. The cyclic depsipeptide didemnin B has demonstrated impressive anticancer activity in preclinical models. Clinical use has been approved but is limited by sparse patient responses combined with toxicity risk and an unclear mechanism of action. From a broad-scale effort to match ant...
متن کاملGenomic analysis of exceptional responders to radiotherapy reveals somatic mutations in ATM
Radiation therapy is a mainstay of cancer treatment, yet the molecular determinants of clinical response are poorly understood. We identified exceptional responders to radiotherapy based on clinical response, and investigated the associated tumor sequencing data in order to identify additional patients with similar mutations. Among head and neck squamous cell cancer patients receiving palliativ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Reviews Cancer
سال: 2014
ISSN: 1474-175X,1474-1768
DOI: 10.1038/nrc3836